• HOIP s ability to build

  2020-06-15

  

  HOIP\'s ability to build linear Ub chains arises from a unique domain that follows directly after the RING2 domain, the linear ubiquitin chain-determining domain (LDD) (Fig. 1). Structures have revealed that the LDD is structurally integrated into RING2, creating a single RING2–LDD unit (Fig. 2D) [4

• Based on the SUMO SIM interaction involved in

  2020-06-15

  

  Based on the SUMO–SIM interaction involved in SUMOD positioning, a SUMO2ΔSBD (SIM-binding domain; Q30A, F31A, I33A) mutant can be investigated that disrupts this important binding interface (Eisenhardt et al., 2015; Meulmeester, Kunze, Hsiao, Urlaub, & Melchior, 2008). In Fig. 4A, multiturnover assa

• br Experimental section br Acknowledgments

  2020-06-13

  

  Experimental section Acknowledgments MIN6 cells were kindly provided by Dr. Junichi Miyazaki, Osaka University. This research was supported in part by the Ministry of Education, Culture, Sports, Science and Technology of Japan (JP16H05099 and JP18H04609 to K.H., and JP16H06574 to T.U.), SENTAN

• Initially we ascertained that if the dose of elastase

  2020-06-13

  

  Initially, we ascertained that if the dose of elastase was sufficient to cause pulmonary emphysema, then pulmonary emphysema could be maintained throughout the study. We found that elastase at 3U was sufficient to cause emphysema that remained over 35 days. In this experimental design of lung diseas

• In principle in vitro techniques for assessing

  2020-06-13

  

  In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized Mometasone furoate lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with recombin

• The primary aim of this study

  2020-06-13

  

  The primary aim of this study was to evaluate DAPK methylation as a tumor marker which is not only detected in the primary tumor but also in the serum of patients. We used matched pre-operative serum samples to determine the correlation of tumor and serum results. Despite an equal methylation freque

• Cytokines are small secreted proteins that mediate and

  2020-06-13

  

  Cytokines are small secreted proteins that mediate and regulate immunity, inflammation, and hematopoiesis. They are produced in response to an immune stimulus. Cytokines regulate the intensity and duration of the immune response by stimulating or inhibiting the activation, proliferation, and/or diff

• AG014699 Another important mediator in fear learning is the

  2020-06-13

  

  Another important mediator in fear learning is the neuropeptide corticotropin-releasing factor (CRF). For example, local repeated administration of CRF into the basolateral amygdala potentiates the acquisition of cue-conditioned fear (Bijlsma et al., 2011) and CRF1 receptor antagonists effectively b

• Though limited to a large cohort

  2020-06-13

  

  Though limited to a large cohort of self-reported healthy individuals, associations between individual Silodosin have been identified which may be clinically significant. Though slight, there is a relationship between the CYP2D6-inferred metabolizer phenotype and the diplotype-predicted activities

• Simon discusses this in the remarks and historical notes sec

  2020-06-13

  

  Simon discusses this in the remarks and historical notes section following the general discussion of dynamically defined Verblunsky coefficients; see [12, pp. 706–707]. He points out that “understanding almost periodic Verblunsky coefficients is an intriguing open area” and in particular describes w

• Emi protein consists of an N terminal regulatory region and

  2020-06-13

  

  Emi2 protein consists of an N-terminal regulatory region and a C-terminal functional region. The C-terminal region contains a destruction box (D-box), which likely competes with APC/C substrates (including cyclin B) for APC/C binding, and a zinc-binding region (ZBR), which somehow inhibits APC/C ubi

• br Experimental Procedures br Author Contributions br Acknow

  2020-06-12

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Estrogen-related receptors (ERRα, ERRβ, and ERRγ) are orphan nuclear receptors whose physiological ligands have not yet been identified. Although ERRs are closely related to estrogen receptors (ERs) they do not res

• By using the C elegans Matrisome

  2020-06-12

  

  By using the C. elegans Matrisome Annotator tool, we found substantial enrichment for matrisome Budesonide in these data sets. Thus, re-analyzing -omic datasets with the C. elegans Matrisome Annotator tool may be useful to generate novel hypotheses about the role of the C. elegans matrisome for vari

• br Experimental br Results and discussion On

  2020-06-12

  

  Experimental Results and discussion On the basis of the information obtained from the studies on RHA/TiO2 nanocomposites, it Halopemide is expected that this reagent can be used as a catalyst for the promotion of the organic reactions. So this reagent was used in the promotion of the conversi

• The three dimensional crystal structure

  2020-06-12

  

  The three-dimensional crystal structure of Ca2+ loaded CaM reveals a dumbbell-shaped molecule with two roughly globular lobes, the N- and C-terminal lobes linked by a long solvent-exposed helix, which has been shown by NMR to be non-helical in its central part and flexible in solution [13]. Each glo

15539 records 818/1036 page Previous Next First page 上5页 816817818819820 下5页 Last page