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To examine the biochemical characteristics
2021-10-22
To examine the biochemical characteristics of FPPS in Drosophila, DmFPPS has been functionally expressed in E. coli. The protein displays properties similar to mammalian FPPS, with some notable differences, including the ability to efficiently couple the homologous substrate, homodimethylallyl dipho
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ANT located in the IMM mediates the exchange
2021-10-22
ANT, located in the IMM, mediates the exchange of ATP/ADP between the mitochondrial matrix and the intermembrane space (IMS) (Brand et al., 2005; Palmieri and Pierri, 2010). Of the 4 known isoforms, ANT1 is the dominant isoform in the heart (Palmieri and Pierri, 2010). Under physiological conditions
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br Potential endogenous agonists of GPR The first endogenous
2021-10-22
Potential endogenous agonists of GPR35 The first endogenously produced chemical that was shown to be able to activate GPR35 was the tryptophan metabolite kynurenic UNC0638 [8]. When human GPR35 was expressed along with a mixture of promiscuous and chimeric G proteins 9, 10 (Box 1) in CHO cells,
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Indeed in women with different causes of epithelial
2021-10-22
Indeed, in women with different causes of epithelial layer damage, HIV infection rates have been reported to be very high [2], [3]. As observed from in vivo studies, disruption of the epithelium due to pathogens [45], [46] or chemical irritants [47], has resulted in women being at a higher risk of H
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Our study has some limitations While our
2021-10-22
Our study has some limitations. While our study provides data from a diverse multi-country setting, we did not have a sufficient sample size to investigate whether the relationship of micronutrients and Thymidine with CD4 recovery differed by country. We relied on measurement of deficiencies based o
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Previous studies showed that pregnancy rate improves when ew
2021-10-22
Previous studies showed that pregnancy rate improves when ewes have a BCS that exceeds a minimum threshold [43]. The pregnancy rate is increased in sheep with BCS ≥2.5 [44] and >2 [45]. In this work, pregnancy rate was higher in the GnRH group with low BCS compared to the hCG and Control groups. Des
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br Conclusion br Introduction The intracellularly generated
2021-10-22
Conclusion Introduction The intracellularly generated metabolite methylglyoxal (MG, 2-oxopropanal) acts as a potent electrophile causing irreparable cellular damage if allowed to build to cytotoxic concentrations [1], [2], [3], [4], [5], [6]. The glyoxalase (Glx) system is an enzyme couple cri
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br Conclusions In summary we have
2021-10-22
Conclusions In summary, we have designed an ultrasensitive electrochemical assay for hOGG1 based on a ratiometric strategy and HCR assisted amplification. The hOGG1 can specifically identify 8-oxo G site on the DNA probes modified on the electrode surface. The subsequent cleavage reaction trigger
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In this study with the use of C N
2021-10-22
In this study, with the use of 13C515N2-labeled glutamine, we observed that 13C515N2-labeled glutamine produces a wide range of NAAG isotopologues and its precursors: NAA and glutamate. The NAAG production from glutamine is consistently more elevated in MYC-ON lymphoma and OVCAR4 compared to MYC-OFF
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br Introduction Prostate cancer is the most
2021-10-22
Introduction Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths in men in the United States, accounting for about 30,000 cancer deaths annually [1]. Epidemiological studies that show geographical variations in prostate cancer incidence and mortalit
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br Other strategies for ferroptosis In addition to ROS gener
2021-10-21
Other strategies for ferroptosis In addition to ROS-generating and GPX4 inactivating nanomaterials, small molecules and genetic manipulation targeting key factors in the ferroptosis pathway have also been tested for their anticancer effects [39,47,48]. Among a myriad of proteins involved in ferro
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DAMPs are endogenous danger signals that can
2021-10-21
DAMPs are endogenous danger signals that can initiate and perpetuate a noninfectious HQNO during cell death [23]. HMGB1 is a well-studied nuclear DAMP in various types of regulated necrosis and has been implicated in the pathogenesis of infection and sterile inflammation. Our current data indicate t
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A series of P P ureas were explored first and
2021-10-21
A series of P3-P4 ureas were explored first and their anti-NS3 protease activity, antiviral properties in a HCV replicon cell-based assay and PK profiles examined. Installation of a methyl group on the P4 side nitrogen Moxidectin of the urea yielded , a molecule which retained intrinsic potency aga
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br Functional organization of postsynaptic glutamate recepto
2021-10-21
Functional organization of postsynaptic glutamate receptors Downstream effects of glutamate receptor positioning Mechanisms underlying the subsynaptic positioning of glutamate receptors Conclusions and future prospects The molecular organization of synapses is undoubtedly a critical dete
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Glutamate activates cationic glutamate gated channels i e
2021-10-21
Glutamate activates cationic glutamate-gated channels (i.e. ionotropic glutamate receptors) that mediate the fast excitatory actions of glutamate. It also activate G protein-coupled receptors, named metabotropic glutamate receptors (mGluRs) (Pin and Bettler, 2016). The eight subtypes of mGluRs are k
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