• br Brief overview of the glutamate

  2022-06-20

  

  Brief overview of the glutamate system and rationale for targeting the glycine site of NMDARs In the central nervous system (CNS), glutamate is the major excitatory neurotransmitter and works in concert with gamma-aminobutyric monensin (GABA), the primary inhibitory neurotransmitter. Together, G

• To maintain low Glu concentrations

  2022-06-20

  

  To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino BAMB-4 sale is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, and

• Human Glucocorticoid Receptor hGR was

  2022-06-20

  

  Human Glucocorticoid Receptor (hGR) was first cloned in 1985 (Hollenburg et al., 1985). It is a modular protein comprised of an N-terminal trans-activating domain (NTD), a C-terminal ligand-binding domain (LBD) and a central DNA- binding domain (DBD). The DBD is highly conserved and has two zinc fin

• All data were analyzed using SAS software

  2022-06-18

  

  All data were analyzed using SAS software (version 9.3, SAS Institute Inc., Cary, NC). Because of very low FFAR1 protein detection (at the detection limit or no signal) in 3 H-BHB cows, quantification was not possible within a linear range and therefore these animals were omitted from the statistica

• Ning et al showed that LPC appeared

  2022-06-18

  

  Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p

• Endotoxin induced pulmonary hypertension is a reproducible f

  2022-06-18

  

  Endotoxin induced-pulmonary insulin receptor is a reproducible finding in various animal models Leeper-Woodford et al., 1991, Weitzberg et al., 1993 and is also a feature of human sepsis where it may affect right ventricular function (Vincent, 1998). Mechanisms such as vasoconstriction and leukocyt

• In the Joint United Nations Program on HIV

  2022-06-18

  

  In 2015, the Joint United Nations Program on HIV/AIDS (UNAIDS) proposed that by 2020, 90% of people living with HIV should be aware of their HIV status, as the first part of 90-90-90 strategy to end AIDS epidemic. Early detection of HIV allows initiating care for proper treatment, which impacts in m

• Regulation of gene expression in mammalian cells is governed

  2022-06-18

  

  Regulation of gene expression in mammalian cells is governed by the epigenetic machinery, which includes several distinctive yet entangled branches. DNA and histone modifying enzymes, non-coding regulatory RNAs, and ATPase-dependent chromatin remodeling proteins all contribute to the dynamic alterat

• br Conclusion The histamine H receptor has been the

  2022-06-18

  

  Conclusion The histamine H3 receptor has been the focus of a great deal of research over the past four decades and in this context, substantial progress has been made in developing H3R-related ligands. The involvement of H3Rs in many neurological disorders has been documented by several lines of

• br Disp Cleavage and Membrane

  2022-06-18

  

  Disp Cleavage and Membrane Trafficking Knowledge of how Disp is regulated in Shh-producing porcine to control ligand deployment has, until recently, remained limited. Early studies examining Disp function in Madin–Darby Canine Kidney (MDCK) cells and Drosophila tissue suggested that it is likely

• Amelogenesis is a complicated process as described

  2022-06-18

  

  Amelogenesis is a complicated process, as described above, and for the last several decades, various animal and human studies have used molecular genetics to identify a number of signaling molecules and gene networks that act at specific stages of the ameloblast life cycle and regulate its patternin

• The discovery that the physiological functions of LPI are

  2022-06-17

  

  The discovery that the physiological functions of LPI are associated with the activation of specific GPR55 membrane receptor [4] has launched a new era of research on this lysophospholipid. However, the activation of membrane receptors by lysophospholipids is extremely complex due to the multitude o

• br Conclusions Beta cell specific

  2022-06-17

  

  Conclusions Beta cell-specific expression in human islets of DGCR2, GBF1, GPR44 and SerpinB10 has not previously been described, although the proteins have partly been characterized in other contexts not related to beta ABT or diabetes. DGCR2, GPR44 and SerpinB10 were negative in all other cell

• Intranasal immunization can induce the activation of IgA sec

  2022-06-17

  

  Intranasal immunization can induce the activation of IgA-secreting plasma cell precursors that are present in NALT and induce IgA antibody-secreting cells; these cells express l-selectin (+), allowing migration to the lymphatic nodes, as well as α4β1 (+), CXCR4 (+), and CCR10 (+), which facilitate m

• Through a large scale phylogenetic analysis of

  2022-06-17

  

  Through a large-scale phylogenetic analysis of UDG superfamily in more than 1000 completely sequenced genomes, it is shown that family 3 Carbamazepine can be separated into two clades with the traditional family 3 SMUG1 as one of them (Fig. 1) [31]. UDG enzymes in another clade are present in eubac

15965 records 443/1065 page Previous Next First page 上5页 441442443444445 下5页 Last page