• Cx has been shown to

  2022-07-29

  

  Cx45 has been shown to be serine phosphorylated by CaMKII, CK1, PKA, and MAPK in HeLa ARP 100 receptor [77], [78]. Phosphorylation by PKA and MAPK were associated with decreased junctional conductance [78], suggesting that phosphorylation of Cx45 may influence conduction properties. Overall, the ro

• br Involvement of gap junctions and

  2022-07-29

  

  Involvement of gap junctions and Panx1 in spinal cord processing of pain information Several studies indicated that GJs in the CNS contribute to pain. A common finding in such studies is that intrathecal administration of GJ blocker attenuates pain behavior. For example, intrathecal CBX attenuate

• When we compared the effects in

  2022-07-29

  

  When we compared the effects in FST induced by GAL and GAL(1–15), we observed that the increase in the immobility induced by GAL(1–15) was significantly higher than the one induced by GAL (Millon et al., 2015). Moreover, in climbing behaviour, GAL(1–15) also induced a stronger decrease in climbing r

• There is a dual inducer of

  2022-07-29

  

  There is a dual inducer of both galanin and super-threshold pain. First, injury-induced pain may stimulate galanin secretion. After peripheral nerve injury, the galanin expression level was upregulated in dorsal root ganglion (DRG), dorsal horn and hypothalamic arcuate of rats [25], [28], [33]. The

• Natural product based drug discovery can be enhanced

  2022-07-29

  

  Natural-product-based drug discovery can be enhanced with computational methods [205]. Because most of the reported small-molecule natural inhibitors of fMLF-induced functional responses were not evaluated in Argatroban binding assays, we used molecular modeling to predict how well these compounds f

• Natural product based drug discovery can be enhanced

  2022-07-29

  

  Natural-product-based drug discovery can be enhanced with computational methods [205]. Because most of the reported small-molecule natural inhibitors of fMLF-induced functional responses were not evaluated in pimaricin binding assays, we used molecular modeling to predict how well these compounds f

• In conclusion we have shown that

  2022-07-29

  

  In conclusion, we have shown that the brain penetrating ability of heteroaryl piperazine and piperadine ureas can be modulated through small structural changes to the heteroarenes, the piperazine or piperidine core, and the biaryl ether tail. Compounds exhibiting / ratios ranging as high as 4.2:1 to

• In conclusion a series of new

  2022-07-29

  

  In conclusion, a series of new 3-carboxamido-5-aryl-isoxazoles was designed, synthesized and screened for their inhibitory potency against FAAH. Their cytotoxicity was determined and their lipophilicity was calculated. Compounds bearing a 3-substituted biphenyl moiety with high Log values displayed

• br Introduction br The histaminergic system in the central

  2022-07-28

  

  Introduction The histaminergic system in the central nervous system The tcY-NH2 receptor is continually processing information through aminergic systems present in the mammalian CNS such as the serotonergic, dopaminergic, noradrenergic and histaminergic systems which function by projecting si

• In order to find better LODs LOQs and

  2022-07-28

  

  In order to find better LODs, LOQs and peak shape researchers used different derivatization agents along with dansyl chloride. However, these procedures required longtime for sample preparation, low recovery, the chance of contamination; products instability and some reagents were unable to derivati

• br Methods br Results br Discussion Exercise results in a

  2022-07-28

  

  Methods Results Discussion Exercise results in a remarkable redistribution of blood flow, which increases in active skeletal muscles but decreases in the splanchnic circulation. The regional blood flow in the kidney, spleen, stomach and intestine was measured by using the microsphere techni

• In tumor cells HK II

  2022-07-28

  

  In tumor cells HK-II induction is mediated by Akt/mTOR pathway [6], [11]. HK-II dynamically shuttles between the mitochondria and cytoplasm under different metabolic conditions. In cardiomyocytes, Akt enhances HK-II binding to mitochondria, setting the heart at a state resistant to ischemic injury [

• In addition to lifestyle factors genetic factors may also in

  2022-07-28

  

  In addition to lifestyle factors, genetic factors may also influence the efficacy of antineoplastic drugs in breast cancer patients.16, 17 The HER2 gene contains several single nucleotide polymorphisms (SNPs). Two of the most investigated HER2 SNPs are Ile655Val (rs1136201) and Ala1170Pro (rs1058808

• Fibronectin protein level was not affected by

  2022-07-27

  

  Fibronectin protein level was not affected by DIF-1, although fibronectin has also been considered a canonical Wnt signaling pathway target gene product [39]. Thus, the canonical Wnt signaling pathway may not be critical for the regulation of the expression of fibronectin in malignant melanoma cells

• PF-477736 It is well known that O tetradecanoylphorbol

  2022-07-27

  

  It is well known that 12-O-tetradecanoylphorbol-13-acetate (TPA) is a tumor promoting agent of skin carcinogenesis in rodents [12]. TPA stimulates a variety of cellular functions in cancer cells, including cell motile activity [13], [14]. In our recent study, when liver epithelial cells were treated

15585 records 395/1039 page Previous Next First page 上5页 391392393394395 下5页 Last page