• Introduction the DNA damage response important implications

  2024-05-06

  

  Introduction: the DNA damage response — important implications for tumour development and treatment Cells are invariably challenged by tens of thousands of lesions inflicted on their DNA everyday (Lindhal, 1993). This DNA damage can be caused exogenously by exposure to different types of radiation

• br Material and methods br Results br Discussion Asparagine

  2024-05-06

  

  Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential Bedaquiline for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial enzyme asparaginase

• br Concluding remarks It is clear

  2024-05-06

  

  Concluding remarks It is clear that a disordered l-arginine homeostasis by changes in arginase, NOS and ADMA activity and expression, is not only vital in the chronic airway diseases, Dacarbazine synthesis and COPD, but also seems to play an important role in many co-morbidities. Unknown, howeve

• br Materials and methods br Results and

  2024-05-06

  

  Materials and methods Results and discussion Conclusion Funding This work was supported by the Canadian Institute of Health Research (CIHR) [grant number FDN-148413] to PS, the National Science and Engineering Research Council of Canada (NSERC) [grant number CRD-399680] to ÉM, and the FR

• Hepatic inflammation and fibrosis are hallmarks of

  2024-05-06

  

  Hepatic Defactinib and fibrosis are hallmarks of the NASH phenotype and are thought to occur in a subset of patients with NAFLD. While it is hypothesized that therapeutic lowering of hepatic lipids will be sufficient to improve hepatic fibrosis and inflammation secondarily, this remains controversia

• The complex role of the human intestinal microbiota is emerg

  2024-05-06

  

  The complex role of the human intestinal microbiota is emerging and its functions has been elucidated when considering energy metabolism, nutrient digestion, vitamin synthesis, epithelial defenses and immune responses [34]. The colon is responsible for salvage of energy and possibly nitrogen from ca

• br Methods br Results br Discussion Agitation

  2024-05-06

  

  Methods Results Discussion Agitation in dementia has recently been defined as a syndrome characterized by inferred or observed evidence of emotional distress associated with at least one behavioral component, i.e. excessive motor activity, verbal or physical aggression (Cummings et al., 201

• br Introduction There are greater than five

  2024-05-06

  

  Introduction There are greater than five million Americans living with Alzheimer's dementia and more than 35 million people worldwide [1], and without a way to stop or slow the progression, there will be nearly a tripling of individuals affected by 2050 (13.8 million) [1]. The urgency to develop

• The lactam emerged as lead candidate due

  2024-05-06

  

  The lactam (6) emerged as lead candidate due to its high selectivity, outstanding potency (against ALK or in clinically known ALK mutants), low in vitro clearance, and low efflux potential. The lactam (6) was selected for further profiling against the resistant ALK mutants. Preclinical rat pharmacok

• br Materials and methods br Results br Discussion Wound

  2024-05-06

  

  Materials and methods Results Discussion Wound healing of the human cornea is a complex process that requires cell migration and proliferation. Corneal wound healing is characterized by major changes in the composition of the ECM such as a massive transitory secretion of fibronectin combine

• br Concluding Remarks and Future Perspectives

  2024-05-06

  

  Concluding Remarks and Future Perspectives Disclaimer Statement Introduction Aldehyde dehydrogenase ALDHs (E.C. 1.2.1.3) are multigene family of NAD(P)+-dependents group of structurally and functionally related ubiquitously distributed enzymes involved in the specific and irreversible oxida

• In this study we demonstrated that DRR protein level in

  2024-05-06

  

  In this study, we demonstrated that DRR1 protein level in GBM tissues was significantly higher compared to normal Furosemide tissues. This data suggested that DRR1 might play a role in the tumorigenesis of glioma. To investigate whether DRR1 could accurately predict the outcome in patients with gli

• Inhibitors of mPGES are considered as safe alternative

  2024-05-03

  

  Inhibitors of mPGES-1 are considered as safe alternative to NSAIDs in the treatment of chronic inflammatory diseases that are characterized by excessive PGE2 production (Bahia et al., 2014; Khurana and Jachak, 2016; Koeberle et al., 2016; Korotkova and Jakobsson, 2014; Norberg et al., 2013; Psarra e

• We conducted the largest drug

  2024-05-03

  

  We conducted the largest drug screen to date in HPV-positive cancers and identified Aurora kinase inhibitors as effective and understudied drugs in HNSCC and CESC. These drugs cause apoptosis and cell cycle arrest in vitro and decrease tumor size in vivo. This is the first published study to demonst

• When skeletal muscle ages there is an

  2024-05-03

  

  When skeletal muscle ages, there is an increase in frailty, which is coincident with a decrease in muscle mass and function—this condition is called sarcopenia (Cruz-Jentoft et al., 2010). It has been shown that one of the major pathways downregulated at the onset of sarcopenia is the mitochondrial

15969 records 163/1065 page Previous Next First page 上5页 161162163164165 下5页 Last page