• In the days before Christmas adverse weather conditions and

  2019-04-29

  

  In the days before Christmas, 1952, adverse weather conditions and the burning of sulphurous coal led to the death of almost 12 000 people in London. Despite improvements in pollution prevention since the “Great Smog”, London continues to experience toxic air pollution linked to thousands of prematu

• Both typhus and typhoid most

  2019-04-29

  

  Both typhus and typhoid most commonly present as undifferentiated febrile illness, defined as fever with no localising features, but have different modes of transmission. Typhoid is transmitted faecal-orally, and typhus is primarily transmitted through insect or mite bites on the skin. is the main

• Thomas Hoeksema por su parte explica

  2019-04-28

  

  Thomas Hoeksema, por su parte, explica la paradoja del título del siguiente modo: “la destrucción (fuego) está moderada por la estabilidad y la armonía (reposo). La relación entre estas dos fuerzas es multidimensional y dialéctica”. Para Hoeksema, el segundo volumen poético de Pacheco se debe entend

• ginsenoside rh2 In the current study we

  2019-04-28

  

  In the current study, we first isolated primary HSCs from rat liver and then treated the ginsenoside rh2 with alcohol. As shown in Fig. 1, the mRNA levels of PCBP2 and type I collagen were increased significantly. In addition, the type I collagen mRNA level was more significantly increased in prima

• Pero todo cambia despu s

  2019-04-28

  

  Pero todo cambia después del exilio en Francia; son los presuntos “bárbaros” los únicos que parecen ser capaces de una auténtica revolución: dirá Bilbao con admiración que ellos fueron los que en 1848 hicieron transporters las “naciones de Europa […] estremecerse como bajo las plantas de Attila”. Lo

• Sorafenib br Potential therapeutic use of PI

  2019-04-28

  

  Potential therapeutic use of PI3Kα and/or pan-PI3K inhibitors in CLL PI3Kδ has been the overwhelming target of choice for PI3K inhibition in CLL; however there is mounting evidence for important roles of other PI3K isoforms in CLL and of functional redundancy between PI3K isoforms in leucocytes i

• In the s systematic case detection and treatment campaigns

  2019-04-28

  

  In the 1960s, systematic case detection and treatment campaigns brought the disease under control, with fewer than 5000 cases reported per year. However, the political instability and conflicts of the FH535 Supplier following decolonisation in countries such as DR Congo, Angola, and Sudan led to th

• Intrahepatic cholangiocarcinoma ICC originates from the

  2019-04-28

  

  Intrahepatic cholangiocarcinoma (ICC) originates from the small intrahepatic ductules or the large intrahepatic ducts proximal to the bifurcation of the right and left hepatic ducts. ICC is the second most common primary malignancy of the liver after hepatocellular carcinoma (HCC). Given the rising

• br Catheter ablation A reentry circuit is supported by compl

  2019-04-28

  

  Catheter ablation A reentry circuit is supported by complex anatomy and a thick and/or damaged myocardium; thus, high-energy RF application is usually required to create the conduction block line through the critical isthmus of the reentry circuit in patients after ToF repair. A large-tip (8mm) a

• The ability of tumors to progress to

  2019-04-28

  

  The ability of tumors to progress to more malignant phenotypes depends on tumor microenvironment. Blood capillaries, made up of endothelial cells, are usually static under physiological conditions but are induced to proliferate by direct exposure to angiogenic factors, for instance, vascular endothe

• Vollmer and colleagues distinctive multilevel modelling

  2019-04-28

  

  Vollmer and colleagues\' distinctive multilevel modelling has potential weaknesses that warrant further investigation. The authors imply that tremendous statistical power is derived from the availability of Demographic and Health Survey data for about 460 000 children and their households. But becau

• Por otra parte en su definici n experiencial

  2019-04-28

  

  Por otra parte, en su definición experiencial y corporal, estas escenas colocan la Historia verdadera en otra dimensión, el relato de viaje. En efecto, lo que caracterizaría buena parte de esta crónica así como las dos primeras cartas cortesianas (al menos) es el relato del viaje de conquista, el én

• Complete surgical resection of the tumor at

  2019-04-26

  

  Complete surgical resection of the tumor at the time of diagnosis is essential towards effective management of PPB. Unfortunately, a large cohort of patients present with an advance stage of disease where the tumor has grown to such an extent to invade surrounding vital structures, hindering the com

• In addition to inducing IKs dysfunction through

  2019-04-26

  

  In addition to inducing IKs dysfunction through dominant-negative loss-of-function effects and defective channel trafficking, mutations in KCNQ1 suppress IKs channel function by reducing the channel affinity of interacting proteins [68,69]. Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor

• OS is Executive Director of the INDEPTH

  2019-04-26

  

  OS is Executive Director of the INDEPTH Network. PB is Director of the WHO Collaborating Centre for Verbal Autopsy and chairs the Scientific Advisory Committee of the INDEPTH Network. The INDEPTH Network is grateful for core funding from Sida, the Wellcome Trust, and the William & Flora Hewlett Foun

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